VI. Earth Life Emergence: Development of Body, Brain, Selves and Societies
2. The Origins of Life
Takeuchi, Nobuto and Paulien Hogeweg. Multilevel Selection in Models of Prebiotic Evolution II: A Direct Comparison of Compartmentalization and Spatial Self-Organization. PLoS Computational Biology. 5/10, 2010. In a follow up to their 2003 paper herein, Utrecht University bioinformaticians offer new pathways to help perceive and factor in these real, prior, endemic dynamics and resultant nested emergences for the welling evolutionary revision to complement and augment post selection.
Takeuchi, Nobuto, et al. On the Origin of DNA Genomes: Evolution of the Division of Labor between Template and Catalyst in Model Replicator Systems. PLoS Computational Biology. Online March 24, 2011. As the extensive Abstract explains, bioinformatic researchers Nobuto, NIH, Paulien Hogeweg, Utrecht University, and Eugene Koonin, NIH, achieve notable insights into how life’s replication process initially got its evolving act together. We resultant people are just beginning to learn the rest of the story. And might one imagine that since material nature innately appears to develop this way, it might in fact be made for this purpose?
At the core of all biological systems lies the division of labor between the storage of genetic information and its phenotypic implementation, in other words, the functional differentiation between templates (DNA) and catalysts (proteins). This fundamental property of life is believed to have been absent at the earliest stages of evolution. The RNA world hypothesis, the most realistic current scenario for the origin of life, posits that, in primordial replicating systems, RNA functioned both as template and as catalyst. How would such division of labor emerge through Darwinian evolution? We investigated the evolution of DNA-like molecules in minimal computational models of RNA replicator systems. Two models were considered: one where molecules are adsorbed on surfaces and another one where molecules are compartmentalized by dividing cellular boundaries. Both models exhibit the evolution of DNA and the ensuing division of labor, revealing the simple governing principle of these processes: DNA releases RNA from the trade-off between template and catalyst that is inevitable in the RNA world and thereby enhances the system's resistance against parasitic templates. Hence, this study offers a novel insight into the evolutionary origin of the division of labor between templates and catalysts in the RNA world. (Abstract)
Takeuchi, Nobuto, et al.
The Origin of a Primordial Genome through Spontaneous Symmetry Breaking.
Veteran theoretical and experimental biologists NT and Kunihiko Kaneko, University of Tokyo and Paulien Hogeweg, Utrecht University go on to perceive a whole genomic complementarity amongst replicative nucleotides in rudimentary bounded cells and autocatalytic processes. As the Abstract notes, an efficient self-organized critical poise between these dual functional stages is then becoming apparent.
The heredity of a cell is provided by a small number of non-catalytic templates. How did these genomes originate? We demonstrate the possibility that genome-like molecules arise from symmetry breaking between complementary strands of self-replicating molecules. Our model assumes a population of protocells, each containing a population of self-replicating catalytic molecules. The protocells evolve towards maximising the catalytic activities of the molecules to increase their growth rates. Conversely, the molecules evolve towards minimising their catalytic activities to increase their intracellular relative fitness.
Trefil, James. How Life Began. Santa Fe Institute Bulletin. Winter, 2006. A substantial NSF grant has been awarded to SFI to systematically study how life first occurred, directed by Harold Morowitz. Two concurrent approaches are planned – bottom up from biomolecules and top down in a reverse-engineering fashion from cellular forms.
…what is exciting and new about this multi-pronged approach to the origin of life is its focus on the fundamental physical and chemical processes that we know were present early in the history of our planet – the processes we know must have given rise to life in the first place. It encourages us to see life not as some highly improbable accident but as a natural outcome of the workings of the physical universe. (7)
Trefil, James, et al. The Origin of Life. American Scientist. May-June, 2009. With co-authors Harold Morowitz and Eric Smith, a state of the art update noted more with quote in An Organic Universe.
Vaidya, Nilesh, et al. Recycling of Informational Units Leads to Selection of Replicators in a Prebiotic Soup. Chemistry & Biology. 20/2, 2013. Vaidya and Niles Lehman, Portland State University chemists, and Sara Walker, Arizona State University astrobiologist, propose that a biomolecular redundancy is at work to aid in life’s complex initiation.
Vaneechoutte, Mario. The Scientific Origin of Life. Jerry Chandler and Gertrudis Van de Vijver, eds. Closure: Emergent Organizations and Their Dynamics. Annals of the New York Academy of Sciences, 2000. The author contends that early life and the scientific enterprise develop in the same way by corresponding molecular and linguistic codes.
Villarreal, Luis and Guenther Witzany. That is Life: Communicating RNA Networks from Viruses and Cells in Continuous Interaction. Annals of the New York Academy of Sciences. Online March, 2019. A UC Irvine biologist and a Telos–Philosophische Praxis, Austria philosopher (search each) continue their project to better explain how life’s biomolecular origins came to be. Herein a novel finesse of ribonucleic and deoxyribonucleic acids, along with viral–like modes, is seen to provide a fuller, more accurate reconstruction.
The conserved results of evolution stored in DNA must be read, transcribed, and translated via an RNA‐mediated process for the development and growth of each individual cell. Thus, all living organisms depend on these RNA‐mediated processes. The precellular evolution of RNAs was crucial to the emergence of cellular life. Here we argue that RNA networks and RNA communication can interconnect precellular and cellular levels. With the reemergence of virology in evolution, it became clear that communicating viruses and subviral infectious genetic parasites are bridging these two levels by invading, integrating, coadapting, exapting, and recombining constituent parts in host genomes for cellular requirements in gene regulation and coordination aims. Therefore, a 21st century understanding of life is of an inherently social process based on communicating RNA networks, in which viruses and cells continuously interact. (Abstract excerpts)
Chemoautotrophic Origin of Life: The Iron-Sulfur World Hypothesis.
Barton, Barry, et al.
Geomicrobiology: Molecular and Environmental Perspectives.
Dordrecht: Springer, 2010.
I once heard the author, a Munich patent attorney and Ph.D. chemist, speak on the subject at a 1984 AAAS meeting in New York City. He has stayed on the case, and is now recognized for crafting a unique integration which this lead chapter summarizes. In so doing, as the quotes express, dichotomous methods of close analysis or overall synthesis, discrete molecule or relational metabolism, can be resolved. In support of an organic cosmos, significant aspects can be gleaned. By way of our human “retrodiction” some twenty “bio-elements” such as Sulfur, Magnesium, Phosphorous, Zinc, and Vanadium are found well suited, as if “preordained,” which seem to act in concert for life to arise and evolve.
At the philosophical level we still are faced with the conflict between mechanistic explanations and teleological judgments. Biochemistry is providing ever more refined mechanistic explanations of the chemistry of life, down to the finest molecular details. A theory of biology, by contrast, would have to treat organisms, i.e., organized beings, as integrated wholes. Biochemistry is reductionistic and mechanistic while biology is holistic and teleological. (1) This then is our problem: to postulate a primordial organism – here termed “pioneer organism,” which is at the same time mechanistic and organizational. Central to this effort will be the notion of a “synthetic autocatalysis,” the chemical equivalent of biological reproduction, which is a chemical reaction mechanism and at the same time a functional whole, and by being synthetic it is endowed from the start with the primary vector of complexity increase. (2)
Wagner, Andreas. The Large-scale Structure of Metabolic Networks: A Glimpse of Life’s Origin? Complexity. 8/1, 2003. As the ‘universal character’ of network dynamics becomes known, their activity in organizing biomolecules and protocells into organic systems brings a novel feature to explain how life began and became increasingly complex.
Walde, Peter, ed. Prebiotic Chemistry. Berlin: Springer, 2005. Volume 259 in the Topics in Current Chemistry. series. Much recent progress via theory and experiment is reported about the procession from simple amphiphilic molecules, which combine both hydrophilic and hydrophobic (water affinity or aversion) properties, to the self-assembly of membrane-bounded minimum protocells. Typical papers discuss rudimentary cell structures, chirality, and amino acid synthesis, whose authors include David Deamer and Eors Szathmary. The tacit implication is a fertile cosmos which innately complexifies to its current human reconstruction and self-witness.
Walker, Sara Imari. Origin of Life: A Problem for Physics. arXiv:1705.08073. The Arizona State University, School of Earth and Space Exploration and Beyond Center for Fundamental Concepts in Science polyscholar continues her insightful syntheses. In this case a succinct entry to this active frontier which expands to a vital reunion with, and grounding in a conducive cosmos. Her project involves gathering many research strands such as RNA world, genetics first, cooperative networks, autocatalysis, self-organization, homochirality, metabolism, biochemistry, information, thermodynamics, criticality, programmable constructors, universality, and more into a composite scenario. This is an achievement in itself, but a translation to an actual “cosmic elephant” these abstractions are trying to express still awaits us.
The origins of life stands among the great open scientific questions of our time. While a number of proposals exist for possible starting points in the pathway from non-living to living matter, these have so far not achieved states of complexity that are anywhere near that of even the simplest living systems. A key challenge is identifying the properties of living matter that might distinguish living and non-living physical systems such that we might build new life in the lab. This review is geared towards covering major viewpoints on the origin of life for those new to the origin of life field, with a forward look towards considering what it might take for a physical theory that universally explains the phenomenon of life to arise from the seemingly disconnected array of ideas proposed thus far. The hope is that a theory akin to our other theories in fundamental physics might one day emerge to explain the phenomenon of life, and in turn finally permit solving its origins. (Abstract)