A. A Familiar Ecode: An Ecosmome to Geonome Complementary Endowment is Found Everywhere

Zimatore, Giovanna, et al. Self-organization of Whole-Gene Expression through Coordinated Chromatin Structural Transition. Biophysics Reviews. September, 2021. Five geneticists posted in Italy, Japan, and Poland including Masa Tsuchiya provide still another, significant genomic example of nature’s persistence to reach and reside at an optimum reciprocal poise.

The human DNA molecule is a long polymer collapsed into the micrometer space of the cell nucleus. This simple consideration leads to gene-by-gene regulation which better contrasts with the physical reality in the presence of cell state transitions that involvef thousands of genes. This state of affairs invites a statistical mechanics approach where specificity arises from a selective unfolding of chromatin driving the rewiring of gene expression patterns. The arising of “expression waves” marking state transitions can be related to chromatin reorganization through self-organized critical control of whole-genome. (Excerpt)

Zimmern, Vincent. Why Brain Criticality is Clinically Revelant. Frontiers in Neural Circuits. August, 2020. A UT Southwestern Medical Center child neurologist provides an actual survey of the palliative implications of this by now accepted, phenomenal condition whence our brains seek and become poised at this optimum dynamic state.

The past 25 years have seen increased number of publications related to criticality in neuroscience. But recent writings on this topic make brief mention of clinical applications to such disorders as epilepsy, neurodegenerative disease, neonatal hypoxia, along with sleep issues and developmental-behavioral pediatrics. In this scoping review, studies of brain criticality involving human data of all ages are evaluated for their clinical relevance. In regard, the prime concepts behind criticality (e.g., phase transitions, long-range temporal correlation, self-organized criticality, power laws, branching processes) will precede their neurological occasion. (Excerpt)

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